Process evaluation for the delivery of a water, sanitation and hygiene mobile health program: findings from the randomised controlled trial of the CHoBI7 mobile health program Md. Sazzadul Islam Bhuyian1 , Ronald Saxton2 , Khaled Hasan2 , Jahed Masud1 , Fatema Zohura1 , Shirajum Monira1 , Shwapon Kumar Biswas1 , M. Tasdik Hasan1 , Tahmina Parvin1 , Ismat Minhaj1 , Kazi Md. Zillur Rahman3 , Nowshin Papri1 , Mahamud-ur Rashid4 , Lubaba Sharin1 , Alana Teman2 , Elizabeth D. Thomas2 , Kelsey Alland2 , Alain Labrique2 , David A. Sack2 , Jamie Perin2 , Munirul Alam1 and Christine Marie George2 1 International Centre for Diarrhoeal Disease Research, Bangladesh(icddr,b), Dhaka, Bangladesh 2 Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 3 University of New South Wales, Sydney, NSW, Australia 4 University of Manitoba, Winnipeg, MB, Canada Abstract objective The Cholera-Hospital-Based Intervention for 7-days (CHoBI7) mobile health (mHealth) program delivers mobile messages to diarrhoea patient households promoting water treatment and handwashing with soap. The randomised controlled trial (RCT) of the CHoBI7 mHealth program demonstrated this intervention was effective in significantly reducing diarrhoea and stunting amoung young children. The objective of this study was to assess the implementation of the CHoBI7 mHealth program in delivering mHealth messages during this RCT. methods 517 diarrhoea patient households with 1777 participants received weekly text, voice and interactive voice response (IVR) messages from the CHoBI7 mHealth program over the 12-month program period. The program process evaluation indicators were the following: the percentage of CHoBI7 mHealth messages received and fully listened to by program households (program fidelity and dose), and household members reporting receiving and sharing an mHealth message from the program in the past two weeks (program reach). results Ninety two percent of text messages were received by program households. Eighty three percent of voice and 86% of IVR messages sent were fully listened to by at least one household member. Eighty one percent of IVR quiz responses from households were answered correctly. Program households reported receiving a CHoBI7 mHealth message in the past two weeks at 79% of monthly household visits during the 12-month program. Seventy seven percent of participants reported sharing a program message with a spouse, 55% with a neighbour and 49% with a child during the program period. conclusion There was high fidelity, dose and reach of mobile messages delivered for the CHoBI7 mHealth program. This study presents an approach for process evaluation that can be implemented to evaluate future mHealth programs. keywords mobile health, diarrhoea, randomised controlled trial, water, sanitation and hygiene Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 6 (clean water and sanitation), SDG 9 (industry, innovation and infrastructure), SDG 17 (partnerships for the goals) Introduction Diarrhoeal diseases result in an estimated 500,000 deaths amoung young children annually in low- and middle-in￾come countries (LMICs) [1]. Previous studies have found that lack of handwashing with soap and water treatment are important risk factors for paediatric diarrhoeal disease [2-4]. Water, sanitation and hygiene (WASH) interventions have the potential to reduce diarrhoeal dis￾eases globally [5]. However, encouraging households to sustain WASH behaviours over time remains a significant public health challenge [6]. Effective and scalable WASH interventions are needed to improve child health in LMICs. © 2020 John Wiley & Sons Ltd 985 Tropical Medicine and International Health doi:10.1111/tmi.13414 volume 25 no 8 pp 985–995 august 2020 Phone-based reminders of public health information have been shown to reduce disease morbidity and increase health-protective behaviours [7-9]. A recent sys￾tematic review found that 15 randomised controlled trials (RCTs) of mobile health (mHealth) interventions resulted in significant improvements in health-protective beha￾viours, and 16 RCTs resulted in significant improvements in clinical outcomes [10]. In the past 10 years, mobile phone access and ownership have doubled globally [11,12]. The total number of mobile phone subscribers in Bangladesh reached over 160 million registered users in 2019, according to the Bangladesh Telecommunication Regulatory Commission [13]. This presents an ideal opportunity to use mobile phones to deliver public health information in Bangladesh. Mobile technology can be used to create automated systems to deliver voice and text mes￾sages to a large number of individuals at a low cost [14]. However, there are only two published studies, to our knowledge, that have evaluated the use of mHealth for delivery of WASH programs to households and no ran￾domised controlled trials of WASH mHealth programs [15,16]. Henry et al. was conducted in Tanzania, and this study targeted 60 youth 18 to 25 years old [15] and focused on text messages on hygiene promotion. This study found that 92% of participants received and responded to program text messages. Tidwell et al. was conducted in India and focused on mobile phone messaging for mothers of young children; it found a modest (~5%) significant improvement in handwashing with soap behaviour [16]. There is an urgent need for rigorous methods to evaluate delivery of WASH mHealth programs. In an effort to reduce diarrhoeal diseases in Bangla￾desh, our research group developed the Cholera-Hospital￾Based Intervention for 7 days (CHoBI7) mHealth pro￾gram. This program delivers automated text, voice and interactive voice response messages promoting handwash￾ing with soap and water treatment behaviours. Messages are sent by a character named Dr Chobi, a doctor at a hospital who calls and texts participants about the pro￾moted WASH behaviours [17]. All diarrhoea patient households receive weekly interactive voice response (IVR), voice and text messages from the CHoBI7 mHealth program for a 12-month period. Mobile mes￾sages are sent using the web-based VIAMO platform [18]. The recent RCT of the CHoBI7 mHealth program demonstrated this program was effective in significantly increasing handwashing with soap and stored drinking water quality, and reducing diarrhoea and stunting in young children [19]. In this study, we assessed the fide￾lity, dose and reach of the CHoBI7 mHealth program through process evaluation conducted during the RCT of this intervention. We used data obtained from the VIAMO platform and participant reports. Methods The RCT of the CHoBI7 mHealth program enrolled 769 diarrhoea patients and 1857 household members from December 2016 to April 2018. The RCT com￾pared the standard recommendation given in Bangladesh to diarrhoea patients (of any aetiology) at discharge on oral rehydration solution use for dehydration (standard message arm) to the CHoBI7 mHealth program with either a single in-person visit for health facility delivery of the program (mHealth with no home visits arm) or health facility delivery of the program plus two home visits (mHealth with two home visits arm). The two home visits were delivered during the one-week high risk period after the diarrhoea patient was discharged from the health facility. Diarrhoea patient households in the mHealth arms were sent weekly IVR, voice and text messages from the CHoBI7 mHealth program over a 12-month period. A summary text message was sent to households after voice and IVR messages, in addition to standalone text messages. Twenty six voice, 14 IVR quiz, 2 IVR (questions about the condition of interven￾tion hardware) and 48 text messages (12 standalone text and 36 summary text messages) were sent to households during the study period. A detailed descrip￾tion of the CHoBI7 mHealth program is published elsewhere [17]. Implementation findings are presented using the Medi￾cal Research Council framework for process evaluation [20]. The adaption and the theory of change for delivery of the CHoBI7 mHealth program is described in detail in our recent publication George et al. 2019 [17]. The CHoBI7 mHealth program was developed through a the￾ory-driven approach informed by the Integrated Behav￾ioral Model for Water, Sanitation and Hygiene (IBM￾WASH) and the Risks, Attitudes, Norms, Abilities and Self-regulation (RANAS) Model [21,22]. Program adap￾tion was conducted based on mobile health workshops, semi-structured interviews and group discussions fol￾lowed by a pilot study. Our goal was to deliver at least 80% of program text, voice and IVR messages to benefi￾ciary households. Therefore, program fidelity was defined by at least 80% of program text, voice and IVR messages being answered/received by beneficiary households. Pro￾gram dose was defined as the percentage of program voice, text and IVR messages answered/received and fully listened to by beneficiary households. Program reach was defined as whether household members (target audience) 986 © 2020 John Wiley & Sons Ltd Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program reported receiving a CHoBI7 program mHealth message in the past two weeks. VIAMO platform process evaluation indicators The following process evaluation indicators were used to assess the CHoBI7 mHealth program based on data from the VIAMO platform: (i) the percentage of CHoBI7 text, voice and IVR messages received (for text messages) or answered (for voice and IVR) by benefi￾ciary households (program fidelity and dose) (received by at least one phone in the household); (ii) the percent￾age of CHoBI7 voice and text messages fully listened to by beneficiary households (program fidelity and dose) (by at least one phone in the household); and (iii) the percentage of households replying correctly to IVR quiz responses (by at least one phone in the household). The VIAMO platform has two classifications for text mes￾sages, either ‘Finished (received)’ or ‘Network Failed’, and ‘Failed’ or ‘Finished (answered)’ for voice and IVR messages. The VIAMO platform can identify whether a text message is received and whether a voice call is answered. The percentage of CHoBI7 text messages received by beneficiary households was calculated by dividing the total number of unique text messages at each time point received by the household by the total number of unique messages sent to the household. For voice and IVR messages, the duration of the recorded message listened to (call duration) can be assessed using the VIAMO platform. If the health promotion content of the voice or IVR message was completely listened to by a household, then it was classified as ‘fully listened to’ (fully completed) otherwise this was classified as ‘partially listen to’. The percentage of CHoBI7 voice and IVR messages fully listened to by beneficiary house￾holds were calculated by dividing the number of unique messages at each time point ‘fully listened to’ by the household by the total number of unique messages sent to the household. In addition, IVR quiz messages prompted beneficiaries to select one of two possible options on questions related to handwashing with soap and water treatment behaviours, and transmission of diarrhoeal diseases. If a listener selected a response, this was classified as ‘replied’ and then assigned to be either ‘correct’ or ‘incorrect’. Participant reports Participant reports were used to assess the percentage of beneficiaries receiving and sharing an mHealth message from the CHoBI7 mHealth program in the past two weeks (program reach). Information was also collected on the percentage of beneficiaries reporting challenges with the mHealth platform during the program period. Participant reports were collected from a mHealth surveillance form administered monthly to enrolled household members 12 years of age or older. To assess whether CHoBI7 mHealth messages sent to households were being received by the primary caregiver, we calcu￾lated the percentage of primary caregivers that reported receiving a CHoBI7 mHealth message in the past two weeks at each time point. Statistical analysis Logistic and linear regression analyses were performed with study arm as the predictor and the process evalua￾tion indicator as the outcome to determine whether there were significant differences in indicators between study arms. All analyses described above were performed using STATA software version 13. Results Seventeen hundred seventy seven participants from 517 households were enrolled in the CHoBI7 mHealth pro￾gram (264 households in the mHealth with no home vis￾its arm and 253 households in the mHealth with two home visits arm) (Table 1). The mean age for program participants was 18 years, and 54% (966/1777) were female. Ninety four percent (487/517) of households had at least one person who could read and write. Forty four percent (230/517) of households reported refrigerator ownership, and 28% (146/517) reported having a con￾crete roof. Twenty three percent of households (121/517) were lost to follow-up at the 12-month time point. Program households received 91% (5425/5987) of standalone text messages and 92% (16451/17831) of summary text messages. Sixty percent of households (311/517) received all standalone text messages sent, and 85% (440/517) of households received over 80% of stan￾dalone text messages sent. Forty nine percent (254/517) of households received all summary text messages sent, and 88% (454/517) of households received over 80% of weekly summary text messages sent. Eighty three percent (9448/11345) of voice messages sent were fully listened to. Six percent of households (29/517) answered all voice messages sent, and 88% (456/517) of households answered over 80% of voice messages sent. Eighty six percent (6618/7669) of IVR messages sent to program households were fully listened to. Fifty nine percent of households (358/517) answered all IVR messages sent, and 93% (482/517) of households answered over 80% of IVR messages sent. © 2020 John Wiley & Sons Ltd 987 Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program There was no significant difference by study arm in the proportion of program messages received for standalone or summary text messages or a significant difference by study arm for IVR messages being fully listened to. The percentage of voice messages fully listened to was signifi￾cantly higher in the mHealth with two home visits arm compared to the mHealth with no home visits arm (P = 0.01, 82% vs. 84%) (Table 2). Program households replied to 68% (4004/5906) of unique IVR quiz messages sent, and 81% (3258/4004) of these quiz responses were correct (Table 3). At Week 3, when asked whether hands should be washed with soap after or before eating, 91% (311/340) of households responded ‘before eating’. At Month 11.75, 83% (219/ 264) of participants responded correctly that contami￾nated water and hands spread germs. The only difference by study arm in the proportion of households that responded correctly to quiz questions was for the Month 4 program message, where more respondents in the mHealth with two home visits arm knew that hands and water could spread germs than the mHealth with no home visits arm (P = 0.04, 87% vs. 78%). For the mHealth with no home visits arm, 73% (132/ 182) of program households (household-level) reported receiving a mobile message from the CHoBI7 mHealth program in the past two weeks at the 6-month time point, and 78% (150/192) at the 12-month time point (Figure 1). For the mHealth with two home visits arm, 77% (151/197) of program households reported receiving a mobile message from the CHoBI7 mHealth program in the past two weeks at the 6-month time point, and 78% (157/201) at the 12-month time point. Seventy one per￾cent (350/492) of program participants (participant-level) at the 6-month time point reported receiving a message from the CHoBI7 mHealth program in the past two weeks, and 69% (414/604) at the 12-month time point (Figure 2). This did not significantly differ by study arm. Seventy percent (249/357) of caregivers reported receiving a message from the CHoBI7 mHealth program in the past two weeks at the 6-month time point, and 67% (240/357) at the 12-month time point. This also did not significantly differ by study arm. Eighty six percent of participants (768/896) reported sharing CHoBI7 mHealth program mobile messages with another individual during the 12 month program period. Seventy seven percent (694/896) of participants reported sharing CHoBI7 mHealth program messages with spouses, 55% (494/896) with neighbours, 49% (443/896) with their children, 24% (215/896) with parents, 21% (190/896) with siblings, 18% (158/896) with in-laws, 18% (161/896) with friends, and 13% (117/896) with co-workers over the 12-month program period. There were no significant differences between study arms for sharing a message with others (Table 4). Eighty one per￾cent (733/896) of participants reported that someone in their household shared a CHoBI7 program mobile mes￾sage with them during the 12 month program period. Seventy four percent of participants (663/896) reported that a spouse shared a CHoBI7 mHealth message with them during the program period, 35% (318/896) Table 1 Baseline population characteristics by study arm mHealth with no home visits arm mHealth with two home visits arm Study households 264 253 All study participants 886 891 Household members of index diarrhoea patients 622 638 Number of primary caregivers 264 253 Number of individuals 12 years of age or older 496 513 Mean study participants per household Mean  SD (Min–Max) 3.4  0.85 (2–7) 3.5  0.93 (2–6) Mean study participants per household (≥ 12 years) Mean  SD (Min–Max) 1.89  0.65 (1–5) 2.03  0.66 (1–5) Baseline household member age Mean  SD (Min–Max) (years) 18  15 (0.08–80) 18  15 (0.08–75) 0–5 years 34% 32% 5–12 years 10% 10% 12–18 years 1% 2% 18 years or greater 55% 56% Gender % female 55% 54% Household roof type Concrete 28% 28% Tin 71% 72% Other <1% 0% Household wall type Concrete 71% 71% Mud 3% 4% Tin 26% 25% Other 0% <1% Household floor type Concrete 97% 96% Other 3% 4% Electricity 93% 92% Refrigerator ownership 45% 44% At least one household member can read and write 95% 94% SD, standard deviation. 988 © 2020 John Wiley & Sons Ltd Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program reported a child in their household, 12% (105/896) reported parents, 7% (60/896) reported siblings, and 7% (65/896) reported in-laws (Table 5). There were no sig￾nificant differences in having a message shared between study arms. Forty nine percent (438/896) of participants reported at least once during the study period that they were too busy to receive program messages, 38% (337/896) reported that they were not able to read a text message, 37% (327/896) reported that mobile messages were not being shared by the phone’s owner, 34%(307/896) reported that their phone was damaged, and 17% (148/ 896) had no one available to read text messages to them. There were no significant differences between study arms for reported challenges (Table 6). Discussion The process evaluation of the CHoBI7 mHealth program demonstrated high fidelity, dose and reach of mobile mes￾sage delivery in both mHealth study arms. Over 80% of voice and IVR quiz messages were fully listened to, and 90% of text messages were received by program house￾holds. The majority of households responded to IVR quiz questions, and 81% of their responses were correct. Fur￾thermore, the majority of households (78%) reported receiving an mHealth message from our program in the past two weeks at our 12-month follow-up. We also observed frequent message sharing within households and with those outside of program households. These findings demonstrate that the CHoBI7 mHealth program presents an effective approach to deliver voice, IVR and text mes￾sages to households in slum areas of Dhaka, Bangladesh. These results complement our recent RCT of the CHoBI7 mHealth program that demonstrated this program was effective in significantly increasing handwashing with soap and stored drinking water quality, and reducing diarrhoea and stunting in young children [19]. A major success of the CHoBI7 mHealth program was the ability to successfully deliver mHealth messages with high reach to the primary caregivers in the household. Phone access for the primary caregiver in the home emerged as an important challenge during our formative research [17]. This is consistent with findings from the Aponjon mHealth program [23]. This mHealth program delivers text messages to women during pregnancy on antenatal care in Bangladesh. Female Aponjon subscribers reported that sometimes program calls were missed because someone else in the household had the phone, and that program messages were often not shared with them. Through tailoring our CHoBI7 mobile messages to encourage message sharing with all household members and through emphasising the importance of primary care￾givers receiving our mobile messages during health facil￾ity visits, we were able to overcome this challenge. It is estimated that 82% of adult males are mobile phone Table 2 Summary of CHoBI7 mHealth program mobile messages sent to households Message type Indicator mHealth with no Home visits arm mHealth with two home visits arm Overall results for both arms n % n % n % p-value Standalone text Sent 3087 -- 2900 -- 5987 -- Failed 307 10% 255 9% 562 9% 0.38 Received 2780 90% 2645 91% 5425 91% 0.71 Summary text Sent 8986 -- 8845 -- 17831 -- Failed 693 8% 687 8% 1380 8% 0.83 Received 8293 92% 8158 92% 16451 92% 0.17 Voice Sent 5684 -- 5661 -- 11345 -- Failed 466 8% 440 8% 906 8% 0.92 Partially Completed 541 10% 450 8% 991 9% 0.06 Fully Completed 4677 82% 4771 84% 9448 83% 0.01 Interactive voice response Sent 3928 -- 3741 -- 7669 -- Failed 418 11% 335 9% 753 10% 0.19 Partially Completed 166 4% 132 4% 298 4% 0.32 Fully Completed 3344 85% 3274 88% 6618 86% 0.32 n is based on the number of unique mobile messages sent to a household. ‘Fully Completed’ is the same as ‘Fully Listen to’ in the manuscript text. One hundred twenty one households were lost to follow-up at the 12 month time point. © 2020 John Wiley & Sons Ltd 989 Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program Table 3 Summary of CHoBI7 mHealth program interactive voice response quiz questions IVR Quiz question mHealth with no home visits arm mHealth with two home visits arm P-value† Households sent messages (N) Received %(n) Replied %(n) Correct %(n) Households sent messages (N) Received %(n) Replied %(n) Correct %(n) IVR Quiz Day 3: How long after adding the chlorine tablet should you wait to drink this water? Correct Answer: 30 min Wrong Answer : 15 min 258 73% (189) 71% (135) 80% (108) 247 81% (201) 73% (147) 84% (123) 0.42 IVR Quiz Week 3: Should you wash your hands with soapy water after or before eating? Correct Answer: Before Wrong Answer : After 255 91% (231) 73% (169) 91% (153) 242 95% (231) 73% (171) 92% (158) 0.54 IVR Quiz Week 5: How many key times are there for hand washing with soapy water? Correct Answer: Four times Wrong Answer : Three times 258 93% (240) 63% (150) 72% (108) 244 95% (231) 68% (158) 72% (113) 0.93 IVR Quiz Week 7: After heating your water until a rolling boil, how will you store this water? Correct Answer: Keep the water covered with a lid Wrong Answer: Keep the water open without any cover 260 90% (234) 67% (156) 76% (118) 242 96% (232) 66% (154) 82% (127) 0.14 IVR Quiz Month 3.75: How many times do you need to wash your hands with soapy water and use safe drinking water in a day? Correct Answer: Every time in every day Wrong Answer: At least once in a day 216 94% (202) 60% (122) 88% (107) 212 91% (192) 71% ( 137) 91% (125) 0.36 IVR Quiz Month 4: How can diarrhea germs spread? Correct Answer: Germs spread by hands and through water Wrong Answer: Germs spread by air 260 92% (239) 74% (178) 78% (139) 245 91% (222) 74% (165) 87% (143) 0.04 IVR Quiz Month 5: How often do I need to clean my buckets? Correct Answer: Every week Wrong Answer : Every day 253 92% (232) 61% (141) 48% (67) 241 92% (221) 58% (128) 48% (62) 0.88 990 © 2020 John Wiley & Sons Ltd Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program Table 3 (Continued) IVR Quiz question mHealth with no home visits arm mHealth with two home visits arm P-value† Households sent messages (N) Received %(n) Replied %(n) Correct %(n) Households sent messages (N) Received %(n) Replied %(n) Correct %(n) IVR Quiz Month 6 : How many days is the high risk period for becoming sick after someone in your home has severe diarrhea? Correct Answer: 7 days Wrong Answer : 14 days 258 88% (228) 70% (160) 80% (128) 240 90% (217) 74% (161) 74% (119) 0.20 IVR Quiz Month 6.75: When do you have to wash your hands with soap, Before or after cutting cucumbers? Correct Answer: Before cutting cucumbers Wrong Answer: After cutting cucumbers 246 89% (216) 63% (136) 90% (123) 220 91% (200) 67% (134) 93% (124) 0.54 IVR Quiz Month 7.75: What do you need to do after washing both hands with soapy water? Correct Answer: You should use a clean cloth Wrong Answer: You should dry your hands on your clothing 255 87% (222) 68% (151) 85% (120) 244 90% (219) 63% (139) 88% (122) 0.46 IVR Quiz Month 8.75: How do you dispense water from your blue bucket for drinking? Correct Answer: By using the tap on the blue bucket Wrong Answer: By dipping a mug or glass in the blue bucket 255 84% (215) 66% (142) 85% (120) 248 88% (218) 71% (154) 90% (138) 0.19 IVR Quiz Month 10.75: How should Aklima boil her water to keep her family safe from severe diarrhea? Correct Answer: She should heat her water until it reaches a rolling boil Wrong Answer: She should heat her water until it becomes hot 254 85% (216) 67% (145) 83% (121) 248 85% (212) 70% (148) 84% (125) 0.81 IVR Quiz Month 11.75: How are the germs that cause severe diarrhea spread? Correct Answer: Germs are spread by contaminated water and hands Wrong Answer: Germs are spread from bad air 251 84% (211) 65% (138) 85% (117) 232 85% (198) 64% (126) 81% (102) 0.41 N and n values are based on the number of households. † P-value for percent of correct IVR quiz responses compared by study arm. © 2020 John Wiley & Sons Ltd 991 Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program owners vs. only 55% of adult females in Bangladesh [24]. Therefore, it is important that future mHealth pro￾grams targeting child health ensure that mobile messages are reaching female caregivers in the household. Another successful aspect of the CHoBI7 mHealth pro￾gram was the high number of beneficiaries that fully lis￾tened to IVR quiz messages and responded correctly. Furthermore, this did not significantly differ by mHealth arm. This finding suggests that home visits are not needed to ensure households correctly answer program quiz questions. The IVR quiz messages present a novel approach to assess awareness on key program behaviours and to tailor program messages accordingly. For exam￾ple, we learned through our IVR quiz messages during the pilot study that households were unclear on the four key times for handwashing with soap. This led us to fur￾ther emphasise these key times during our RCT. We also learned during the pilot that beneficiaries often took quizzes together as a family in the evenings [17]. This finding suggested that IVR quizzes could serve as an approach to engage several household members at once in mobile message content. This is the first study to our 87% 77% 74% 74% 81% 73% 72% 71% 78% 77% 78% 78% 91% 85% 79% 81% 78% 77% 71% 83% 79% 82% 79% 78% 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Month 1 Month 2 Month 3 Month 4 Month 5 Month 6 Month 7 Month 8 Month 9 Month 10 Month 11 Month 12 mHealth with no home visits arm mHealth with two home visits arm Households reporting receiving a CHoBI7 mHealth message in the past 2 weeks Study month Nn = 194 n = 200 n = 179 n = 187 n = 174 n = 171 n = 182 n = 169 n = 170 n = 181 n = 159 n = 169 n = 192 n = 171 n = 189 n = 175 n = 176 n = 197 n = 175 n = 172 n = 186 n = 178 n = 188 n = 201 Figure 1 Households reporting receiving a CHoBI7 mHealth message in the past 2 weeks over the study period. 85% 77% 74% 75% 75% 71% 67% 70% 73% 73% 71% 69% 88% 79% 74% 74% 74% 70% 64% 68% 71% 71% 68% 67% 0% 10% 20% 30% 40% 50% 70% 60% 80% 90% 100% Month 1 Month 2 Month 3 Month 4 Month 5 Month 6 Month 7 Month 8 Month 9 Month 10 Month 11 Month 12 Participant report Caregiver report Participants reporting receiving CHoBI7 a mHealth message in the past 2 weeks Study month Nn = 483 n = 370 n = 426 n = 442 n = 476 n = 492 n = 513 n = 484 n = 546 n = 481 n = 604 n = 317 n = 357 n = 419 n = 330 n = 448 n = 349 n = 325 n = 322 n = 357 n = 315 n = 306 n = 323 n = 298 Figure 2 Participants and caregivers reporting receiving a CHoBI7 mHealth messages in the past 2 weeks over the study period. 992 © 2020 John Wiley & Sons Ltd Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program knowledge to use IVR quizzes to engage beneficiaries in a WASH program. Two-way text messaging has been asso￾ciated with improved medication adherence practices compared to one-way texting; however, the literature on the impact of voice IVR messages is limited [25]. Our finding that 86% of IVR messages were fully listened to by beneficiaries is consistent with a previous study in Senegal that used IVR educational questions as part of a mobile learning program on management of contracep￾tive side effects and misconceptions among mid-wives and nurses. This study found that 80% of these IVR mes￾sages were received by beneficiaries [26]. Future studies should evaluate the effectiveness of IVR quiz messages in encouraging other WASH behaviours. Through our process evaluation, we identified key chal￾lenges to CHoBI7 mHealth program implementation. A common challenge was not being able to read text mes￾sages. However, it is important to note that only 17% of beneficiaries reported that no one in the household could read a text message for them. In addition, over 94% of program households report at least one person in the household that could read and write. Therefore, most beneficiaries were able to receive the content of text mes￾sages, even if they could not read the messages them￾selves. The literacy rate in Bangladesh for females over 15 years of age is 70% and 76% for males [27]. This finding highlights the importance of including voice mes￾sages in mHealth programs. Most mHealth programs in LMICs employ either text or voice messages; rarely, are both used [28]. Another challenge was beneficiaries being too busy to receive program messages at 49%. We tried to overcome this challenge by sending messages in the Table 4 Participants reporting sharing a CHoBI7 mHealth mes￾sage with others over the study period (Months 1–12) (N = 896) Shared with mHealth with no home visits arm %(n) mHealth with two home visits arm %(n) P-value* Any sharing 85% (367) 87% (401) 0.43 Spouse 76% (328) 79% (366) 0.24 Neighbour 54% (232) 57% (262) 0.37 Children 51% (220) 48% (223) 0.43 Parents 23% (100) 25% (115) 0.54 Sibling 20% (88) 22% (102) 0.54 In-Law 19% (81) 17% (77) 0.42 Friends 19% (83) 17% (78) 0.37 Co-Worker 12% (54) 14% (63) 0.61 *P-value is a comparison of proportions by study arm. Table 5 Participants reporting someone shared a CHoBI7 mHealth message with them over the study period (Months 1– 12) (N = 896) Someone shared mHealth with no home visits arm %(n) mHealth with two home visits arm %(n) P-value* Any sharing 79% (344) 84% (389) 0.08 Spouse 73% (317) 75% (346) 0.60 Children 36% (156) 35% (162) 0.75 Parents 11% (46) 13% (59) 0.33 Sibling 6% (25) 8% (35) 0.29 In-Law 7% (30) 8% (35) 0.72 *P-value is a comparison of proportions by study arm. Table 6 Reported challenges with CHoBI7 mHealth program over the study period (Months 1–12) (N=896) Challenge mHealth with no home visits arm %(n) mHealth with two home visits arm %(n) P-value* Participants were too busy to receive mobile messages 50% (216) 48% (222) 0.56 Not being able to read text messages 37% (162) 38% (175) 0.91 Mobile messages not being shared by phone owner 38% (163) 35% (164) 0.49 Damage to household phone 35% (153) 33% (154) 0.51 No one available in the household to read text messages for them 18% (78) 15% (70) 0.24 Poor cell phone reception made voice calls hard to hear 14% (61) 10% (46) 0.06 Accidentally deleted text messages before reading it 3% (13) 3% (13) 0.86 Full inbox blocked incoming messages 3% (14) 2% (10) 0.32 Accidentally hung up on voice calls before message finished 5% (21) 3% (14) 0.16 Distracting/noisy background made it hard to hear the voice calls 6% (25) 6% (29) 0.76 *P-value is a comparison of proportions by study arm. © 2020 John Wiley & Sons Ltd 993 Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program evening when most household members were home [17]. Our approach is consistent with an mHealth program in Senegal that found that users accessed the program the most in the evening [29]. Future studies may consider evaluating the effectiveness of sending text and voice messages based on the time window requested for each individual household. Mobile message sharing was high among beneficiaries with the majority reporting sharing CHoBI7 mHealth messages with spouses, neighbours, children, parents, sib￾lings, in-laws, friends or co-workers. This finding is con￾sistent with our formative research which found that participants valued the content of program messages and thought that it was important to share the content of these messages with others to help to improve their health [17]. Additional work is needed to identify the spillover effects of the CHoBI7 mHealth program to other households. This study has some limitations. First, the study was conducted only in Dhaka and therefore cannot be gener￾alised to rural areas in Bangladesh. Second, we focused our study on diarrhoea patient households, so these find￾ings cannot be generalised to other populations. Third, we focused on households that reported phone owner￾ship. Future studies should include those households that have shared access to phones. This study has several strengths. First, the monthly mHealth surveillance allowed us to determine whether participants were receiving program mHealth messages and the challenges they were encountering. Second, the use of the process evaluation indicators developed from the VIAMO platform allowed us to determine whether program mobile messages were being received, answered and fully listened to, and whether quiz IVR messages were answered correctly. Third, the 12-month duration of the study allowed us to observe trends in fidelity indi￾cators over time. Conclusion The CHoBI7 mHealth program was implemented with high fidelity, dose and reach. Through process evaluation, we identified robust indicators that can be used to track the progress of mHealth programs. This included the per￾centage of voice and IVR messages fully listened to and the percentage of voice, text and IVR messages received and answered as a measure of program dose and fidelity, and the number of household members that received and shared a program message as a measure of program reach. This study presents an approach for process evalu￾ation that can be implemented to evaluate future mHealth programs globally. Acknowledgements This research was supported by a USAID grant awarded to Johns Hopkins School of Public Health. We thank USAID for their support. We thank the study participants and the following individuals for their support with the implementation of this study: Professor Abul Khair Mohammad Shamsuzzaman, Professor Be-Nazir Ahmed, Fosiul Alam Nizame, Khobair Hossain, Jahed Masud, Ismat Minhaj Uddin, Rafiqul Islam, Maynul Hasan, SM. Arifur Rahman, Abdullah Al Morshed, Zakir Hossain, Kabir Hossain, Amal Sarker, Abul Bashar Sikder, Abdul Matin, Sadia Afrin Ananya, Lubna Tani, Farhana Ahmed, Tahera Taznen, Marufa Akter, Akhi Sultana, Nasrin Akter, Laki Das, Abdul Karim, Shirin Akter, Khan Ali Afsar and Wasim Ahmed Asif. We also thank hospital staff for their support. icddr,b acknowledges the govern￾ments of Bangladesh, Canada, Sweden, and United King￾dom, for providing core/unrestricted support. References 1. Collaborators GDD. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Dis￾ease Study 2015 (vol 17, pg 909, 2017). 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Successful mlearning pilot in senegal: delivering family planning refresher training using interactive voice response and SMS. Glob Health Sci Pract 2015: 3: 305–321. 27. Bangladesh UNESCO. 28. Higgs ES, Goldberg AB, Labrique AB et al. Understanding the role of mHealth and other media interventions for behavior change to enhance child survival and development in low- and middle-income countries: an evidence review. J Health Commun 2014: 19(Suppl 1): 164–189. 29. Diedhiou A, Gilroy KE, Cox CM et al. Successful mLearn￾ing pilot in senegal: delivering family planning refresher training using interactive voice response and SMS. Glob Health 2015: 3: 305–321. Corresponding Author Christine Marie George, Associate Professor, Associate Professor, Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room E5535, Baltimore, MD 21205-2103, USA. Tel.: +1 410 955 2485; E-mail: cmgeorge@jhu.edu © 2020 John Wiley & Sons Ltd 995 Tropical Medicine and International Health volume 25 no 8 pp 985–995 august 2020 Md. S. Islam Bhuyian et al. Evaluation of the delivery of a water, sanitation, and hygiene mobile health program